//Flu Vac time

Flu Vac time

Seasonal Influenza

Caused by influenza viruses

Photo Credit: Cynthia Goldsmith Content Providers(s): CDC/ Dr. Terrence Tumpey. X 100,000



UK, 2020 – 2021


the national flu immunisation programme will be absolutely essential to protecting vulnerable people

and supporting the resilience of the health and care system

Mild to severe illness

Higher viral doses, the more sick people became


Old, young, co-morbidities


Annually (US) since 2010

9 million – 45 million illnesses

140,000 – 810,000 hospitalizations

12,000 – 61,000 deaths


Clinical features in children

Fever, which may be as high as 103°F (39.4°C) to 105°F (40.5°C)

Body aches, which may be severe


Sore throat

Cough that gets worse


Runny or stuffy nose




Possible complications in children



Salts (electrolytes)

Worsening of long-term medical problems

Brain dysfunction such as encephalopathy

Sinus problems and ear infections

In rare cases, death

Initial concern

Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine (Clinical Infectious Diseases, 2012)


We were able to observe a statistically significant increased risk of confirmed noninfluenza respiratory virus infection among TIV recipients

Covid-19: Risk of death more than doubled in people who also had flu, English data show


Odds of death were 2.27 times higher than in people with SARS-CoV-2 alone

possible synergistic effects in coinfected people

Safety of Influenza Vaccine during COVID-19 (September 2020, Journal of Clinical and Translational Science, Cleveland Clinic)


The convergence with influenza season could result in significant morbidity and mortality

Patients (n = 18,868) tested for COVID-19

4,138 flu vac, 2019-2020

9,082 not flu vaccinated

Vaccinated group

Higher BMI

On more meds

More co-morbidities


Blood work

Is someone had flu vac and tested positive for SARS-CoV-2

Unadjusted analysis shows:

Vaccinated individuals were less likely to test positive for SARS-CoV-2

More likely to be hospitalized

More likely to be admitted to the ICU and die during hospitalization

But, once adjusted

Influenza vaccination was unrelated to incidence of SARS- CoV-2 infection

Increased risk for worse hospital outcomes was not related to influenza vaccination

In people with COVID-19, influenza vaccination did not impact risk for hospitalization

Or ICU admission

Or hospital mortality


Influenza vaccination does not increase the incidence of COVID-19

or worsen the related morbidity or mortality

Providing reassurance that the vaccination strategy for global influenza should proceed as planned during the COVID-19 pandemic

Surveillance data needs to be prospectively collected in fall 2020

Study the outcome of concurrent SARS-CoV-2 and influenza infection

Assess any interaction between influenza vaccinations, a newly developed vaccine against coronavirus, influenza and COVID-19 infection

Odds of death were 2.27 times higher than in people with SARS-CoV-2 alone